Vaccine and Immunization
I know what you're thinking. What's the difference?
The IPV is a set of three intravenous injections containing inactivated poliovirus. This vaccine is more expensive and requires skilled staff to administer, but it does not have the danger of vaccine activated paralytic poliomyelitis (VAPP).
The OPV is a set of three oral doses containing attenuated poliovirus. This vaccine is much cheaper to administer, but it carries the risk of mutating into a virulent form (VAPP).
The chart below delineates the differences between the two vaccines.
The IPV is a set of three intravenous injections containing inactivated poliovirus. This vaccine is more expensive and requires skilled staff to administer, but it does not have the danger of vaccine activated paralytic poliomyelitis (VAPP).
The OPV is a set of three oral doses containing attenuated poliovirus. This vaccine is much cheaper to administer, but it carries the risk of mutating into a virulent form (VAPP).
The chart below delineates the differences between the two vaccines.
Inactivated Polio Vaccine (IPV)
Duration of Immunity Medium
Cost High
Route of Administration Injection
Skilled Staff Needed Yes
Stimulates IgG antibody In Blood
Inadequate response in No
some tropical countries
Involuntary transmission to No
non-vaccinated persons
Possible transformation to No
virulent poliomyelitis
Contraindicated in pregnancy No
or immunodeficient states
Duration of Immunity Medium
Cost High
Route of Administration Injection
Skilled Staff Needed Yes
Stimulates IgG antibody In Blood
Inadequate response in No
some tropical countries
Involuntary transmission to No
non-vaccinated persons
Possible transformation to No
virulent poliomyelitis
Contraindicated in pregnancy No
or immunodeficient states
Oral Polio Vaccine (OPV)
Long
Low
Oral
No
In gut
Yes
Yes
Yes, but rare
Yes
Long
Low
Oral
No
In gut
Yes
Yes
Yes, but rare
Yes